What Is Ketamine?
Ketamine is a dissociative anesthetic with established surgical uses and a growing role in psychiatry for treatment-resistant depression and other conditions.
Classification: Other › Ketamine
Key Takeaway
Ketamine is an FDA-approved anesthetic and has FDA approval (as esketamine) for treatment-resistant depression. Unsupervised recreational use carries significant risks.
Why This Matters
Ketamine was developed in the 1960s as a surgical anesthetic. Its unique dissociative effects at sub-anesthetic doses have led to its use in modern psychiatric care for treatment-resistant depression, suicidal ideation, and in some cases PTSD and chronic pain syndromes. Esketamine (Spravato) has FDA approval as a nasal spray for treatment-resistant depression. Ketamine-assisted therapy clinics have grown rapidly. Risks include bladder toxicity with heavy recreational use, dissociation, and potential for misuse.
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Frequently Asked Questions
What is ketamine?
A dissociative anesthetic used for surgery and, increasingly, for treatment-resistant depression and other mental health conditions.
How is ketamine used for depression?
Low doses are administered intravenously, intramuscularly, or as a nasal spray under medical supervision. Effects often begin within hours to a day.
Is ketamine safe?
Medical-grade ketamine in controlled settings has a good safety profile. Heavy recreational use carries real risks including bladder damage and dissociation.
